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Table 1 (Continued)
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Criteria Used to Evaluate Importance of Uncertainty Sources
Table 1 (Concluded)
Uncertainty
Ease with Which
Type of
and/or
Uncertainty Can
Uncertainty2
Uncertainty4
Variability1
Be Quantified?3
Uncertainty Source
Effects Assessment
Toxicity end points for ecological receptors
u,v
Model
Moderate
High
Toxicity end points based on body burdens
Toxicity end points for human receptors
u,v
Model
Moderate
High
Dose-response models for carcinogens and noncarcinogens
Intraindividual/intraspecies
u,v
Parameter
Easy
Low
u,v
Parameter
Easy
Low
Interspecies
u,v
Parameter
Easy
Moderate
Exposure period extrapolation
Lowest observed adverse effect level to no observed adverse effect level
u,v
Parameter
Easy
Low
u
Model
Moderate
NR
Timing of exposure (e.g., exposure during sensitive life stages)
u,v
Model
Moderate
High
Toxicity of complex mixtures of COC (synergism, antagonism)
Risk Characterization
Hazard/toxicity quotient approach
u,v
Model
Difficult
NR
Potential recovery of populations
u,v
Model
Difficult
NR
Estimation of population-level effects
u,v
Model
Difficult
Moderate
(Sheet 3 of 3)

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