Acenaphthylene Cas No. 208-96-8

Acenaphthylene

Cas No. 208-96-8

Potential sources and exposure

Acenaphthylene is a PAH. The reader is referred to the general profile on

PAHs for exposure information.

Physical and chemical properties

Value

Property

Molecular weight

152.2 g/mol

Water solubility

3.93 ppm at 24 C

-2

Vapor pressure

2.9 10 at 20 C

Koc

2,500 mL/g

log Kow

3.7

-3

Henry's Law Constant

1.48 10 atm-m /mol

Toxicity

Little information regarding the acute or chronic toxicity of acenaphthylene is

available.

There are no long-term studies in the literature that adequately evaluate the

carcinogenicity of acenaphthylene, nor are there any data from epidemiologic

studies which correlate acenaphthylene exposure with an increased risk of

cancer. A skin-painting study in mice produced negative results (IRIS 1992).

Structurally, acenaphthylene is similar to other low molecular weight polycyclic

aromatic hydrocarbons that are considered to be noncarcinogenic.

Acenaphthylene is classified as a Group D carcinogen by the U.S. Environmental

Protection Agency (USEPA) based on the lack of human carcinogenicity data

and inadequate data from animal bioassays.

Positive results have been reported from a single mutagenicity test in which

acenaphthylene was tested in a strain of Salmonella typhimurium in the presence

of liver microsomal activation (USEPA 1982). Other tests in Salmonella have

been negative (IRIS 1992). There is currently no RfD for acenaphthylene,

although based on structure-activity relationships with anthracene, an oral RfD

of 0.3 mg/kg-day is recommended.

Toxicokinetics

Like other PAH compounds, acenaphthylene is oxidized by liver enzymes to

form water-soluble derivatives that can be excreted in urine. No data were

Appendix D Toxicological Profiles