Benzo(k)Fluoranthene (11,12-Benzo(k)fluoranthene) Cas No. 207-08-9

Benzo(k)Fluoranthene

(11,12-Benzo(k)fluoranthene)

Cas No. 207-08-9

Potential sources and exposure

Benzo(k)fluoranthene is a PAH. The reader is referred to the general profile

on PAHs for exposure information.

Physical and chemical properties

Value

Property

Molecular weight

252.3 g/mol

4.3 10-3 mg/L at 25 oC

Water solubility

5.0 10-7 mm Hg at 20 oC

Vapor pressure

5.5 105 mL/g

Koc

log Kow

6.06

3.94 10-5 atm-m3/mol

Henry's Law Constant

Toxicity

Although there are no human data that specifically link exposure to

benzo(k)fluoranthene to human cancers, benzo(k)fluoranthene is a component of

complex mixtures that have been associated with human cancer. These include

soot, coke oven omissions, and cigarette smoke (USEPA as cited in IRIS 1992).

IARC concluded that there is sufficient evidence for the carcinogenicity of

benzo(k)fluoranthene in experimental animals. Benzo(k)fluoranthene has been

administered by skin painting, subcutaneous injection, and intrapulmonary

injection. USEPA has classified benzo(k)fluoranthene as a probable human

carcinogen (B2).

Toxicokinetics

Like other PAH compounds, benzo(k)fluoranthene is oxidized by liver

enzymes to form water-soluble derivatives that can be excreted in urine. No

information was available regarding DNA adduct formation or absorption

factors. Because of their high lipid solubility, PAHs are believed to be

distributed throughout the body. Relative to other tissues, they tend to localize in

body fat and fatty tissues.

D14

Appendix D Toxicological Profiles