Benzo(ghi)Perylene (1,12-Benzoperylene) Cas No. 191-24-2

Benzo(ghi)Perylene

(1,12-Benzoperylene)

Cas No. 191-24-2

Potential sources and exposure

Benzo(ghi)perylene is a polycyclic aromatic hydrocarbon (PAH). The reader

is referred to the general profile on PAHs for exposure information.

Physical and chemical properties

Value

Property

Molecular weight

276.3 g/mol

7 10-4 mg/L at 25 oC

Water solubility

1.03 10-10 mm Hg at 25 oC

Vapor pressure

1.6 106 mg/L

Koc

log Kow

6.51

5.34 10-8 atm-m3/mol

Henry's Law Constant

Toxicity

Although there are no human data that specifically link exposure to

benzo(ghi)perylene to human cancers, it is found in complex mixtures that have

been associated with human cancer. These include soot, coke oven emissions,

and cigarette smoke (IRIS 1992).

IARC (1983) and USEPA (IRIS 1992) concluded that the available data are

inadequate to evaluate the carcinogenic potential of benzo(ghi)perylene and is

classified as a Group D carcinogen by the USEPA based on the lack of human

carcinogenicity data and inadequate data from animal bioassays. Based on a

study in which benzo(g,h,i) perylene increased lung tumor incidence when

implanted into rat lungs, it was reported that the potency of this compound

relative to benzo(a)pyrene was 0.022.

Negative tumorgenicity results were obtained for benzo(ghi)perylene in skin

painting studies using mice (IRIS 1992). Mutations due to benzo(ghi)perylene

were evident in invitro bacterial mutagenicity tests (IARC 1983).

Toxicokinetics

No data are available regarding the formation of carcinogenic metabolites,

DNA adduct formation, enzyme induction, or absorption.

D19

Appendix D Toxicological Profiles