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Chrysene
Cas No. 218-01-9
Potential sources and exposure
Chrysene is a (PAH). The reader is referred to the general profile on PAHs
for exposure information.
Physical and chemical properties
Property
Value
Molecular weight
228.3 g/mol
1.8 10-3 mg/l at 25 oC
Water solubility
6.3 10-9 mm Hg at 25 oC
Vapor pressure
2.0 105 ml/g
Koc
log Kow
5.61
1.05 10-6 atm-m3/mol
Henry's Law Constant
Toxicity
Although there are no human data that specifically link exposure to chrysene
to human cancers, chrysene is a component of mixtures that have been associated
with human cancers. These include coal tar, soots, coke oven emissions, and
cigarette smoke (IARC 1983). USEPA has classified chrysene as a Group B2, or
probable human carcinogen, on the basis of evidence of carcinogenicity from
mouse skin painting and intraperitoneal chrysene injections in male mice which
caused an increased incidence of liver tumors. In mouse skin painting assays,
chrysene tested positive in both initiation and complete carcinogen studies. The
relative tumorigenic potency of chrysene was compared with the potencies of
five other polycyclic aromatic hydrocarbons in mouse skin painting assays tested
using similar protocols (USEPA 1984). The ranking was as follows:
benzo(a)pyrene > dibenz(a,h)anthracene > benzo(b)fluoranthene >
benz(a)anthracene > indeno(1,2,3-cd)pyrene > chrysene.
There is limited evidence that chrysene is mutagenic in short-term assays
(IARC 1983). There are no experimental data on the teratogenicity of chrysene
in mammals. There is no information on the potential effects of chrysene on
other endpoints of toxicity.
It was estimated that chrysene had a relative potency to B(a)P of
approximately 0.0044. This number can be used in the relative potency method
to estimate a cancer potency factor.
D28
Appendix D Toxicological Profiles

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