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Page Title: Fluorene Cas No. 86-73-7
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Fluorene
Cas No. 86-73-7
Potential sources and exposure
Fluorene is a (PAH). The reader should refer to the general profile on PAHs
for exposure information.
Physical and chemical properties
Property
Value
Molecular weight
166.7g/mol
1.69 mg/L at 25 oC
Water solubility
7.1 10-4 mm Hg
Vapor pressure
Koc
7,300 mL/g
log Kow
4.2
6.4 10-5 atm-m3 /mole
Henry's Law Constant
Toxicity
Due to the lack of data on the toxicity of fluorene to humans, IARC (1983)
concluded that the available data in experimental animals was inadequate to
permit an evaluation of the carcinogenicity of fluorene. The USEPA's
Carcinogen Assessment Group has classified fluorene in Group D: Not
classifiable as human carcinogen (IRIS 1992).
The RfD for oral exposure to fluorene is 0.04 mg/kg-day, based on
subchronic exposure to flluorene in mice by oral gavage. The LOAEL is
250 mg/kg-day based on hematological effects; the NOAEL is 125 mg/kg-day.
Toxicokinetics
Like other PAH compounds, fluorene is oxidized by liver enzymes to form
water-soluble derivatives that can be excreted in urine. No information is
available regarding dermal or oral absorption coefficients.
Due to their high lipid solubility, PAHs are believed to be distributed
throughout the body. Relative to other tissues, they tend to localize in body fat
and fatty tissues. Elimination of PAHs is primarily via the hepatobiliary tract.
Ecological effects
The reader is requested to review the toxicity profile for the PAHs for
information regarding ecological effects.
D38
Appendix D Toxicological Profiles

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