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 available regarding dermal or oral absorption coefficients. Because of their high
lipid solubility, PAHs are believed to be distributed throughout the body.
Relative to other tissues, they tend to localize in body fat and fatty tissues.
LaVoie and coworkers (1982 as cited in IARC 1983) detected the 2,3-
dihydrodiol metabolite of fluoranthene which is mutagenic in bacterial tests with
an exogenous activation system.
Ecological effects
The reader is requested to review the toxicity profile for the PAHs for
information regarding ecological effects.
References
Integrated Risk Information System (IRIS) on-line database. (1992).
International Agency for Research on Cancer (IARC). (1983). "IARC
monographs on the evaluation of the carcinogenic risk of chemicals to
humans," Polynuclear aromatic compounds, Part 1, Chemical, environmental
and experimental data, Volume 32. World Health Organization, Lyon,
France.
D41
Appendix D Toxicological Profiles
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