Indeno(1,2,3-cd)Pyrene (2,3-Phenylenepyrene; 2,3-o-Phenylenepyrene) Cas No. 193-39-5

Indeno(1,2,3-cd)Pyrene

(2,3-Phenylenepyrene; 2,3-o-Phenylenepyrene)

Cas No. 193-39-5

Potential sources and exposure

Indeno(1,2,3-cd)pyrene is a PAH. The reader should refer to the general

profile on PAHs for exposure information.

Physical and chemical properties

Property

Value

Molecular weight

276.34 g/mol

-1

Water solubility

6.20 10 ppm at 25 C

-10

Vapor pressure

1.0 10

mm Hg at 20 C

Koc

1.6 10 mL/g

log Kow

6.5

-8

Henry's Law Constant

6.86 10 atm-m /mol at 20 C

Toxicity

Although there are no human data that specifically link exposure to

indeno(1,2,3-cd)pyrene to human cancers, indeno(1,2,3-cd)pyrene is a

component of mixtures that have been associated with human cancer. USEPA

has classified indeno(1,2,3-cd)pyrene as a B2 or probable human carcinogen on

the basis of positive results in mice and bacterial mutation assays. Indeno(1,2,3-

cd)pyrene has produced tumors in mice following lung implants, subcutaneous

injection, and dermal exposure (IRIS 1992).

The relative tumorigenic potency of indeno(1,2,3-cd)pyrene was compared

with the potencies of five other polycyclic aromatic hydrocarbons in mouse skin

painting assays conducted using similar protocols (USEPA 1984). The ranking

was as follows: B(a)P > dibenzo(ah)anthracene > benzo(b)fluoranthene >

benzo(a)anthracene > indeno(1,2,3-cd)pyrene > chrysene.

Indeno(1,2,3-cd)pyrene induced mutations bacterial assays in Salmonella

typhimurium strain TA 100 at a concentration of 20 ug/plate and in strain TA 98

at a concentration of 2 ug/plate in the presence of an exogenous metabolic

activating system (IARC 1983). Due to the equivocal mutagenicity testing data,

IARC (1983) considered the available evidence inadequate to classify

indeno(1,2,3-cd)pyrene as a mutagen.

D42

Appendix D Toxicological Profiles