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Page Title:
Dermal Contact with Chemicals In Water |
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 Dermal Contact with Chemicals In Water
In order to convert an external dose to an absorbed dose in the dermal
pathway, a dermal absorption factor is applied to the EPC. Dermal absorption
factors are selected based on EPA Region 1 Guidance and simple structure
activity relationships.
EPCW CR ET EF ED
Absorbed Dose(mg / kg - day) =
(E3)
BW AT
where
CW =
Chemical concentration in water (mg/liter)
Skin surface area available for contact (cm2)
SA
=
PC
=
Chemical-specific dermal permeability constant (cm/hour)
ET
=
Exposure time (hours/day)
EF
=
Exposure frequency (days/year)
ED
=
Exposure duration (years)
Volumetric conversion factor for water (1liter/1,000cm3)
CPCf =
BW
=
Body weight (kg)
AT
=
Averaging time (period over which exposure is averaged:
days)
E3
Appendix E Human Exposure Equations
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