 |
||
|
|
||
| |||||||||||||||
|
|
 Example 18: Intake Calculation for the Consumption of Commercially Harvested Flounder
The risk assessor will calculate a Potential Average Daily Dose of total PCBs due to consumption of
winter flounder exposed to the disposal site. The EPC (concentration of total PCBs in the flounder from
the area of the site) and FI (fraction of the total catch from the area of the site) have been calculated
previously. Note that the EPC is generally expressed as ug/g, although in the intake equation, it is
necessary to convert that to mg/kg. The State Department of Marine Fisheries has indicated, in this
hypothetical example, that a flounder ingestion rate of 0.11 kg per meal is a conservative estimate of
flounder consumption.
ADDpot (mg/kg/day) = EPC H Abs H IR H FI H EF H ED
BWavg H AT
where
EPC
= (3.3 ug/g) = 3.3 mg/kg
Abs
=1
IR
= 0.11 kg/meal
FI
= 0.006
EF
= 52 meals/year
ED
= 9 years
BWavg = 70 kg
AT
= 70 years (365 days/year) = 25,550 days
ADDpot(mg/kg/day) = 3.3 mg/kg H 0.11 kg/meal H 0.006 H 52 meals/yr H 9 yr
70 kg H 25,550 days
ADDpot = 5.6 H 10 -7 mg/kg/day
This is the incremental lifetime average daily intake for the consumption of commercially harvested
flounder using conservative, reasonable maximum exposure assumptions.
Toxicity Assessment
This section summarizes the general toxicological information necessary for the
completion of the human health risk assessment. The purpose of the toxicity
assessment is to provide an estimate of the relationship between the extent of
exposure to a contaminant and the likelihood and/or severity of adverse health
effects. It considers several types of toxicological information, including human,
epidemiological, and animal data. The toxicity profiles provide summaries of the
toxicity assessment. Appendix D provides toxicological profiles for the
90
Chapter 4 Human Health Risk Assessment
|
|
Privacy Statement - Press Release - Copyright Information. - Contact Us - Support Integrated Publishing |
