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 Risk Characterization involves the integration of estimates of exposure
developed as part of the exposure assessment with health effects information
developed as part of the toxicity assessment.
The products of the Risk Characterization section in a human health risk
assessment should be:
a. Carcinogenic risk estimates for the reasonable maximum exposed
individuals from each pathway, contaminant, and each species of seafood
that have been impacted by potential contamination at the dredged material
disposal site.
b. Hazard index to evaluate the potential for noncarcinogenic effects from
each pathway and COC.
Carcinogenic risks. The potential for carcinogenic effects is the estimated
incremental probability of an individual's developing cancer over a lifetime. This
probability is the product of the average daily dose and the CSF. Carcinogenic risk
estimates should be calculated by multiplying the chronic (lifetime) average daily
intake over a lifetime of exposure by the CSF. Carcinogenic risks should be summed
for all pathways for each COC species ingested, unless there is evidence to support
segregation of the ingested species.
The equation for estimating incremental lifetime cancer risk (ILCR) for each
COC consumed is:
ILCR = Lifetime ADDpot H CSF
(7)
The ILCR due to consumption of contaminated seafood impacted by the dredged
material disposal site should be estimated by using the lifetime ADDpot that was
calculated in the exposure assessment. This should be done for each receptor and
species ingested by those receptors.
The total incremental lifetime cancer risk is:
Total ILCR = 3 ILCRn
(8)
where
ILCRn = the incremental lifetime cancer risk estimate for the nth
seafood species.
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Chapter 4 Human Health Risk Assessment
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