Appendix D: Toxicological Profiles

Appendix D

Toxicological Profiles

Acenaphthene

Cas No. 83-32-9

Potential sources and exposure

Acenaphthene is a polycyclic aromatic hydrocarbon (PAH). The reader

should refer to the general profile on PAHs for exposure information.

Physical and chemical properties

Property

Value

Molecular weight

154.2 g/mol

Water solubility

3.42 mg/L at 25 C

-3

1.55 10 mm Hg at 20 C

Vapor pressure

Koc

4,600 mL/g

log Kow

-5

9.1 10 atm-m /mole

Henry's Law Constant

Toxicity

Acenaphthene has been shown to be irritating to the skin and mucous

membranes and to cause vomiting following ingestion.

A review of the reported literature indicates that there are no conclusive

experiments demonstrating the carcinogenic potential of acenaphthene. Studies

using several different bacterial test systems provide no evidence of

mutagenicity. No information concerning its teratogenicity or reproductive

toxicity is available.

The oral RfD of 0.06 mg/kg-day for acenaphthene is based on subchronic

study in mice. Four groups of CD-1 mice (20/sex/group) were gavaged daily

with acenaphthene for 90 days. Liver weight changes accompanied by

Appendix D Toxicological Profiles