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Page Title: Benzo(ghi)Perylene (1,12-Benzoperylene) Cas No. 191-24-2
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Benzo(ghi)Perylene
(1,12-Benzoperylene)
Cas No. 191-24-2
Potential sources and exposure
Benzo(ghi)perylene is a polycyclic aromatic hydrocarbon (PAH). The reader
is referred to the general profile on PAHs for exposure information.
Physical and chemical properties
Value
Property
Molecular weight
276.3 g/mol
7 10-4 mg/L at 25 oC
Water solubility
1.03 10-10 mm Hg at 25 oC
Vapor pressure
1.6 106 mg/L
Koc
log Kow
6.51
5.34 10-8 atm-m3/mol
Henry's Law Constant
Toxicity
Although there are no human data that specifically link exposure to
benzo(ghi)perylene to human cancers, it is found in complex mixtures that have
been associated with human cancer. These include soot, coke oven emissions,
and cigarette smoke (IRIS 1992).
IARC (1983) and USEPA (IRIS 1992) concluded that the available data are
inadequate to evaluate the carcinogenic potential of benzo(ghi)perylene and is
classified as a Group D carcinogen by the USEPA based on the lack of human
carcinogenicity data and inadequate data from animal bioassays. Based on a
study in which benzo(g,h,i) perylene increased lung tumor incidence when
implanted into rat lungs, it was reported that the potency of this compound
relative to benzo(a)pyrene was 0.022.
Negative tumorgenicity results were obtained for benzo(ghi)perylene in skin
painting studies using mice (IRIS 1992). Mutations due to benzo(ghi)perylene
were evident in invitro bacterial mutagenicity tests (IARC 1983).
Toxicokinetics
No data are available regarding the formation of carcinogenic metabolites,
DNA adduct formation, enzyme induction, or absorption.
D19
Appendix D Toxicological Profiles

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