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 preparations (IARC 1983) and mouse skin in organ culture (IARC 1983). The
5,6-oxide was found to bind to cellular macromolecules in mammalian cells
(IARC 1983). Nucleoside adducts have been detected in mouse skin following
topical application of DB(a,h)A but were not characterized (IARC 1983).
No information on the tissue distribution or excretion of DB(a,H)A could be
located. Because of their high lipid solubility, PAHs are believed to be
distributed throughout the body. Relative to other tissues, they tend to localize in
body fat and fatty tissues.
Ecological effects
The reader is requested to review the toxicity profile for the PAHs for
information regarding ecological effects.
References
International Agency for Research on Cancer (IARC). (1983). "IARC
monographs on the evaluation of the carcinogenic risk of chemicals to
humans," Polynuclear aromatic compounds, Part 1, Chemical, environmental
and experimental data, Volume 32. World Health Organization, Lyon,
France.
U.S. Environmental Protection Agency. (1984). "Health effects assessment for
polycyclic aromatic hydrocarbons," EPA-540/1-86/013, Cincinnati, OH.
D33
Appendix D Toxicological Profiles
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