Fluoranthene (Idryl; 1,2-(1,8-Naphthylene)benzene; Benzo(jk)fluorene) Cas No. 206-44-0

Fluoranthene

(Idryl; 1,2-(1,8-Naphthylene)benzene;

Benzo(jk)fluorene)

Cas No. 206-44-0

Potential sources and exposure

Fluoranthene is a PAH. The reader is referred to the general profile on PAHs

for exposure information.

Physical and chemical properties

Value

Property

Molecular weight

202.30 g/mol

0.206 mg/L at 25 oC

Water solubility

5.0 10-6 mm Hg

Vapor pressure

3.8 104 mL/g

Koc

log Kow

4.9

6.5 10-6 atm-m3/mol

Henry's Law Constant

Toxicity

Fluoranthene has been tested for carcinogenicity, with negative results, in

several tests including skin painting studies (as cited in IARC 1983) and a

subcutaneous injection study (as cited in IARC 1983). USEPA has not classified

fluoranthene with regard to its carcinogenicity due to inadequate evidence (IRIS

1992). However, equivocal evidence for mutagenicity of fluoranthene in short-

term bacterial and mammalian tests has been reported (IRIS 1992).

The RfD for oral exposure to fluoranthene is 0.04 mg/kg-day, based on a

study in mice in which subchronic exposure by gavage was associated with

kidney toxicity, increased liver weights and alterations in blood characteristics

(IRIS 1992).

A study of fluoranthene's developmental toxicity was performed in which

intraperitoneal injection to pregnant mice resulted in an increased rate of fetal

resorption (IRIS 1992).

Toxicokinetics

Like other PAH compounds, fluoranthene is oxidized by liver enzymes to

form water-soluble derivatives that can be excreted in urine. No information is

D40

Appendix D Toxicological Profiles