Toxicokinetics - trdoer40195

Toxicokinetics

There are no toxicokinetic data of indeno(1,2,3-cd)pyrene in man (USEPA

1980). In general, many polycyclic aromatic hydrocarbons (PAHs) can produce

toxicity after inhalation, oral, or dermal exposure. Thus, it is believed that they

are readily absorbed after exposure by these routes. Because of their high lipid

solubility, PAHs are believed to be distributed throughout the body. Relative to

other tissues, they tend to localize in body fat and fatty tissues. PAHs are

generally metabolized by the microsomal mixed function oxidase system and

eliminated primarily via the hepatobiliary tract.

Ecological effects

The reader is requested to review the toxicity profile for the PAHs for

information regarding ecological effects.

References

Integrated Risk Information System (IRIS) on-line database. (1992).

International Agency for Research on Cancer (IARC). (1983). "IARC

monographs on the evaluation of the carcinogenic risk of chemicals to

humans," Polynuclear aromatic compounds, Part 1, Chemical, environmental

and experimental data, Volume 32. World Health Organization, Lyon,

France.

U.S. Environmental Protection Agency. (1980). "Ambient water quality criteria

for polycyclic aromatic hydrocarbons," EPA 440/5-80-069, Washington, DC.

U.S. Environmental Protection Agency. (1984). "Health effects assessment for

polycyclic aromatic hydrocarbons," EPA-540/1-86/013, Cincinnati, OH.

D43

Appendix D Toxicological Profiles