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into the skin where it may remain rather than entering the systemic circulation.
Following inhalation exposure, nickel tends to accumulate in the lungs. Nickel
can cross the placenta and it can accumulate in breastmilk. Regardless of the
exposure route, absorbed nickel is excreted in the urine.
Ecological effects
a. Bioaccumulation. Nickel concentrations in plants are generally low,
< 150 mg/kg dry weight, but occasional reports will show much higher
concentrations of 150 to 700 mg/kg. Likewise, invertebrate
concentrations are low, usually < 5 mg/kg. Nickel cannot be considered
a significant, widespread contaminant except at certain site-specific
points. Uptake in invertebrates occurred principally through the water
and ingested particulate nickel was excreted. In fish, concentrations
again are generally low, < 0.5 mg/kg wet weight, but instances of higher
concentrations do exist near polluted areas (1 to 2 mg/kg wet weight).
b. Toxic Effects to Aquatic Organisms. Nickel (Ni2+) is considered
moderately to highly toxic to most aquatic plant species. To
invertebrates, Ni2+ is one of the least toxic inorganic agents. To both
marine and freshwater fish, Ni2+ is relatively nontoxic but when exposed
to low levels over extended periods effects include reduced skeletal
calcification and reduced diffusion capacity of gills. Both acute and
D53
Appendix D Toxicological Profiles
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