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Evaluate Existing Information
For Animal Uptake
Tier I
Information
YES
Sufficient
For a Decision ?
NO
Animal Uptake
NO
Is exposure a
Decision
concern?
YES
Tier II
Non Polar Organic COCs
All other COCs
Calculate Theoretical Uptake
Potential
Information
YES
NO
Sufficient
For a Decision ?
Animal Uptake
Decision
Conduct Animal Uptake
Tests
Tier III
Information
YES
Sufficient
For a Decision ?
Animal Uptake
Decision
NO
Case Specific Study
Or
Risk Assessment
Tier IV
Animal Uptake
Decision
Figure 8-1. Flowchart illustrating tiered evaluation approach for the animal uptake pathway
8-4
Chapter 8
Animal Bioaccumulation
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