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Page Title:
Listing of genes consistently responding at all doses for the given compound/mixture. (cont.) |
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 ERDC TN-DOER-R4
September 2004
2,3,7,8-TCDD
2,3,7,8-TCDD
2,3,7,8-TCDD
Gene
2.5 ng/L (low)
7.5 ng/L (medium)
100 ng/L (high)
Location
Gene ID
Up-regulated genes
A06k
Caudal-type homeobox protein 2
40
<0.001
38
<0.001
65
0.009
(CDX2); CDX3
B03n
D-type cyclin-interacting protein 1
189
0.002
164
0.003
204
<0.001
(DIP1); GCIP;
C01e
Soluble epoxide hydrolase (SEH);
82
0.007
36
0.029
60
<0.001
cytosolic epoxide hydrolase (CEH;
EPHX2; EPH2); epoxide
hydratase
C06e
Solute carrier family 7 member 7
75
0.007
46
0.021
47
0.001
(SLC7A7); y+L-type amino acid
transporter 1 (Y+LAT1)
C14m
ADP-forming succinate-CoA ligase 93
<0.001
113
0.000
287
<0.001
beta subunit (SUCLA2)
E02b
Connective tissue growth factor
67
0.013
67
0.021
130
<0.001
(CTGF)
E03h
Small inducible cytokine subfamily
144
0.002
67
0.011
39
0.004
A member 11 (SCYA11); CC
chemokine eotaxin
E04c
Uromodulin; Tamm-Horsfall
61
0.012
35
0.031
179
<0.001
urinary glycoprotein
E06d
Ephrin type-A receptor 2; epithelial 34
0.006
17
0.005
64
0.001
cell kinase (ECK); tyrosine-protein
kinase receptor ECK
F01k
Leukemia inhibitory factor receptor 90
0.004
38
0.025
65
<0.001
(LIFR)
F06f
Sperm-associated antigen 6
120
<0.001
43
0.001
133
<0.001
(SPAG6); REPROSA1
F06l
Beta crystallin B2 (CRYBB2); BP
147
0.002
63
0.016
183
<0.001
F09a
6-O-methylguanine-DNA
88
0.007
68
0.006
314
<0.001
methyltransferase (MGMT);
methylated-DNA-protein-cysteine
methyltransferase
F10c
DNA polymerase beta (POLB)
174
0.002
65
0.003
185
0.001
F10e
DNA damage repair &
55
0.002
24
0.001
55
0.011
recombination protein 54 homolog
(RAD54)
F13c
p53-induced gene 8 (PIG8);
88
0.005
60
0.013
137
<0.001
etoposide-induced mRNA
F13k
Erythrocyte membrane protein
221
<0.001
71
0.002
69
0.001
band 7.2 (EPB72); stomatin
F14j
Testis-enhanced gene transcript
39
0.021
44
<0.001
101
0.003
(TEGT); BAX inhibitor 1
NOTE: The contents of this technical note are not to be used for advertising, publication, or
promotional purposes. Citation of trade names does not constitute an official endorsement or
approval of the use of such products.
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