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Page Title:
Listing of genes consistently responding at all doses for the given compound/mixture. |
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 ERDC TN-DOER-R4
September 2004
PAH mixture
PAH mixture
PAH mixture
Gene
17.4 g/L (low)
174 g/L (medium)
1740 g/L (high)
Location
Gene ID
Up-regulated genes
A06g
Homeobox protein A4 (HOXA4);
46
0.040
23
0.003
25
0.013
HOX1D; homeobox 1 cluster gene
4 homolog (HOX1.4)
A11a
Fli1 proto-oncogene
28
0.045
213
<0.001
75
0.003
A13l
Lupus LA ribonucleoprotein;
36
0.025
24
<0.001
41
0.002
Sjogren syndrome type B antigen
(SSB)
C05a
Microsomal glutathione S-
24
0.033
62
<0.001
101
0.009
transferase 1 (MGST1); GST12
C06a
Erythrocyte urea transporter (UTE;
32
0.030
124
<0.001
65
<0.001
UT1); solute carrier family 14
member 1 (SLC14A1); HUT11;
RACH1
G43
Cytoplasmic beta-actin (ACTB)
416
<0.001
125
0.001
92
<0.001
G45
60S ribosomal protein L13A
233
<0.001
260
0.003
116
0.023
(RPL13A); 23-kDa highly basic
protein
Down-regulated genes
A07e
MAX protein
0.015
0.044
0.008
0.019
0.003
0.002
B05n
Intercellular adhesion molecule 2
0.008
<0.001
0.015
0.005
0.019
0.032
(ICAM2); CD102 antigen
B10e
JunD proto-oncogene
0.019
0.049
0.009
0.003
0.007
0.010
D02j
5,6-dihydroxyindole-2-carboxylic
0.021
0.036
0.011
0.003
0.011
0.015
acid oxidase (DHICA oxidase);
tyrosinase-related protein 1 (TRP-
1); catalase B; glycoprotein-75
(GP75)
D10l
Inhibitor of apoptosis protein 3
0.007
<0.001
0.013
0.004
0.015
0.022
(API3; IAP3); X-linked inhibitor of
apoptosis protein (X-linked IAP;
XIAP); IAP-like protein
F13l
Heart & neural crest derivatives-
0.007
0.018
0.009
0.020
0.005
0.012
expressed protein 1 (HAND1)
F14a
KE05 protein
0.006
0.014
0.010
0.023
0.003
0.002
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