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 Equilibrium-partitioning sediment guidelines ........................................ 21
Tier III Evaluation ......................................................................................... 22
Water-column toxicity tests .................................................................... 22
Sediment bioassays ................................................................................. 23
Benthic bioaccumulation ........................................................................ 24
Tier IV Evaluation......................................................................................... 27
Tier IV chronic bioassays ....................................................................... 27
Uncertainties of Tier IV evaluation ........................................................ 29
5--Uncertainty in Tier IV Risk Assessments ...................................................... 30
Problem Formulation/Hazard Identification.................................................. 30
Development of conceptual model ......................................................... 30
Assessment and measurement end points ............................................... 32
Exposure Assessment .................................................................................... 33
Estimation of exposure point concentrations .......................................... 33
Bioaccumulation of COCs ...................................................................... 36
Effects Assessment........................................................................................ 45
Toxicity end points for ecological receptors........................................... 45
Toxicity end points based on body burdens............................................ 46
Human receptors: Dose-response models for carcinogens and
noncarcinogens..................................................................................... 47
Extrapolation........................................................................................... 48
Toxic effects of mixtures ........................................................................ 50
Physiology and biology of receptors....................................................... 51
Risk Characterization .................................................................................... 51
Estimation of population-level effects from effects on individuals ........ 52
Joint distributional analysis .................................................................... 53
Temporal considerations: Potential for recovery of populations ............ 53
COC Characterization ................................................................................... 54
Selection of Reference Sediment .................................................................. 54
Trophic Transfer............................................................................................ 58
Chronic Bioassays ......................................................................................... 58
Assessment and Measurement End Points .................................................... 58
Fate and Transport Models ............................................................................ 58
Toxicity End Points Based on Body Burdens for Ecological Receptors....... 59
Dose-Response Models for Human Receptors .............................................. 59
Toxicity of Complex Mixtures ...................................................................... 59
The Need for Field Validation....................................................................... 60
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